External radiation therapy as salvage in patients with post radical prostatectomy prostate cancer in biochemical relapse, 10-year experience

Abstract

OBJECTIVE: To present the results of our experience during the period 2010-2020 in patients with PR in biochemical relapse using RT as rescue treatment, in the Oncological Radiotherapy services. METHOD: 119 patients were selected during the period 2010-2020 who met the inclusion criteria, treated with RT as rescue. RESULTS: The median age was 66 years. In relation to the risk classification, Intermediate Unfavorable represented 38.7%, Intermediate Favorable 28.6%, Low risk 15.1%, High 14.3%, Very High and Not Accurate 1.7% respectively. The most used irradiation technique was VMAT with 94.1%, followed by IMRT was 5.0% with, and CRT3D 0.8%. 83.2% of patients did not present acute GI complications, 12.6% presented Grade 1 complications and 4.2% Grade 2. GU complications occurred in 68.1% (Did not occur), 28.6% Grade 1 and 3.4%, Grade 2. The OS at 5 years is 98.5% +/- 1.5%, and at 10 years it was 92.4%, +/-7.6%. . The SLRL at 5 years was 98.6%, +/- 1.4%; and at 10 years 86.2%, +/- 6.1%; SCE at 5 years was 100% and at 10 years 97.3%, +/- 2.7%. The SLRD at 5 years was 98.5%, +/- 1.5%, at 10 years 74.4%, +/- 24.6%. CONCLUSION: Our results demonstrate that the administration of RT as rescue treatment in post-RP patients in biochemical relapse is a safe and effective treatment in the CL of the disease, OS and CSS.