Variation of CRP, ESR and leukocytes during uncomplicated acute appendicitis

Abstract

Objective: to investigate the variation of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and leukocytes, during the first 24 hours of uncomplicated acute appendicitis,, in patients operated in the General Surgery service of  CMDLT since November 2018 to February 2022. Methods: research observational, descriptive, analytical and retrospective about values ​​of CRP, ESR and leukocytes of patients with uncomplicated acute appendicits confirmed by biopsy.  The statistical treatment used was Shapiro Wilk W and Shapiro Wilk P (p:0.005). Results: 111 patients with acute appendicitis were identified, to whom inclusion-exclusion criteria were applied, it was obteneid a sample of 30 patients with uncomplicated acute appendicitis, which was classified as early (<24 hours of evolution) in 14 patients and non-early (>24 hours of evolution) in 16 patients. The mean values ​​obtained in the early uncomplicated acute appendicitis group were: leukocytes = 14,393 cells/mm3;  CRP = 2.64 mg/dl, ESR = 18.6 mm. In the late uncomplicated acute appendicitis group, the mean values ​​were: leukocytes = 12,766 cells/mm3;  CRP = 2.60mg/dl and ESR = 19.1mm. comparing the results of these biomarkers with normal values, the difference was statistically significant for leukocytes and CRP;  not so for ESR. Conclusion: In this research it was shown that the CRP value rises in acute appendicitis uncomplicated  even in the early phases. This finding contributes to the use of CRP as a paraclinical method in this group of patients.