Predictive factors of high cardiovascular risk in premenopausal and menopausal women. Analytical observational study

Abstract

Incidence of cardiovascular disease (CVD) increases after menopause. This study analyzes the behavior of clinical and paraclinical characteristics in premenopausal and menopausal women and estimates cardiovascular risk (CVR) to establish the predictive factors of high CVR in these stages. Observational analytical study of cohort type 3 transversal. The data is from 81 female patients in the premenopause or menopause period, 44 (54.32%) in premenopause and 37 (45.67%) in menopause. The age of the sample was 48.57 ± 5.12 years, and the age of onset of menopause was 49.72 ± 3.88 years. In the variables evaluated, only a statistically significant difference was found for total cholesterol 187.60 ± 33.09 mg/dl in premenopause and 220.91 ± 60.12 mg/dl in menopause (p=0.004). The calculated CVR was lower in premenopause than in menopause, 3.26 ± 4.79 and 7.04 ± 4.82 respectively, representing a 2.2-fold increase in CVR in menopause (p = 0.002). In menopause it was evidenced that polycystic ovarian syndrome (PCOS) is a predictor of high CVR p=0.001, as well as dyslipidemia in the family p=0.000, the presence of irregular menstrual cycles at some point in life proved to be a predictive factor for high CVR p=0.003. The 3 factors are independent predictors of high CVR for menopause (Sample attrition 18.3%).