Three-dimensional conformal external beam radiation therapy of filodes tumors of the breast: retrospective analysis. Experience of 15 years.

Abstract

Introduction: Phyllodes Tumor (TF) is a fibroepithelial neoplasia with a tendency to recurrence that represents less than 1% of all primary breast tumors. It presents as a nodular lesion and is classified as benign, borderline, and malignant. For borderline or malignant TF, the initial treatment is partial mastectomy followed by adjuvant RT. Objective: The objective of this observational, descriptive, retrospective cohort study was to evaluate the experience in the treatment of adjuvant radiotherapy in patients with TF, treated at the different GURVE centers (2006-2021). Methods: 4889 clinical histories were reviewed, due to the low worldwide incidence of these tumors, 12 patients with TF were found in a period of 15 years. The collected data were placed in a database for further statistical analysis. Results: 11 patients between 26 and 75 years old formed the sample. 7 malignant, 3 benign and 1 borderline were reported. 73% underwent radical or total mastectomies. The only complication presented was dermatitis, 18% presented discrete erythema: grade I and 82% desquamation in patches: grade II, improving with topical treatments. 9% presented local recurrence and 91% live without disease. The median follow-up was 94.93 months. At 10 years, overall survival was 100% and disease-free survival was 81.7%. Conclusion: Adjuvant RT is highly recommended for patients with borderline or malignant TF, as it has been effective in decreasing recurrence rates and increasing survival.