Type 2 diabetes mellitus with positive anti-glutamic acid decarboxylase antibodies

Abstract

Differential diagnosis between the different types of diabetes in the age group between 25 and 45 years is complex. In type 1 and 2 diabetes, other even less documented varieties occur, in which genetic predisposition, immunological findings and unstable insulin secretion overlap. Starting from this premise, two clinical cases are discussed where the presence of autoimmunity against beta cells is demonstrated in two patients who developed hypoglycemia after pharmacological treatment and required only metformin to maintain their metabolic control. Moving from the binary perception of an entity that has demonstrated syndromic behavior is a task that must begin to be prioritized to achieve precision in the diagnosis and treatment of adult diabetes.